tert-Butanol → HCID 67465458, compound

Participants

Reaction Steps

To a solution of 2-(cyclopropylmethoxy)-5-(methoxymethoxy)pyridine-4-carboxylic acid (810 mg) in tert-butyl alcohol (16 mL) were added diphenylphosphorylazide (0.831 mL) and N,N-diisopropylethylamine (0.669 mL), and the mixture was refluxed for 11 hr. The solvent was evaporated under reduced pressure, brine was added thereto, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (737 mg).

Provenance & Evidence