Imidazole → HCID 178472498, compound

Participants

Reaction Steps

A solution of ethyl trans-4-hydroxycyclohexanecarboxylate (5 g), tert-butyl(chloro)diphenylsilane (7.93 mL) and imidazole (2.17 g) in DMF (50 mL) was stirred at room temperature overnight and extracted with ethyl acetate and water. The obtained organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was purified by silica gel chromatography (hexane/ethyl acetate) to give the title compound (10.1 g).

Provenance & Evidence