Tetrabutylammonium Fluoride → HCID 178521554, compound

Participants

Reaction Steps

A solution of a solution (1.0 M, 2.72 mL) of 2-(trans-4-{[tert-butyl(diphenyl)silyl]oxy}cyclohexyl)-6-(cyclopropylmethoxy)-1,3-benzoxazole (714 mg) and tetrabutylammonium fluoride in THF in THF (5 mL) was stirred at room temperature overnight and extracted with ethyl acetate and water. The obtained organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was purified by silica gel chromatography (hexane/ethyl acetate) to give the title compound (311 mg).

Provenance & Evidence