Morpholine, 4-(chloroacetyl)- → HCID 178521451, compound

Participants

Reaction Steps

A suspension of trans-4-[6-(cyclopropylmethoxy)-1,3-benzoxazol-2-yl]cyclohexanol (311 mg), 4-(chloroacetyl)morpholine (532 mg) and tert-butoxy potassium (365 mg) in THF (5 mL) was stirred at room temperature overnight and extracted with ethyl acetate and water. The obtained organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was purified by silica gel chromatography (hexane/ethyl acetate) to give the title compound (427 mg).

Provenance & Evidence