HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → 10-(4-Methyl-1-piperazinyl)-thieno[3,4-b][1,5]benzothiazepine fumarate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | Fumarate | HCID 5460307 | — |
| Reactant | 4-(Thieno[3,4-b][1,5]benzothiazepin-10-yl)-1-piperazineethanol hemifumarate | HCID 131711520 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 10-(4-Methyl-1-piperazinyl)-thieno[3,4-b][1,5]benzothiazepine fumarate | HCID 12703434 | — |
Reaction Steps
10-Chloro-thieno[3,4-b][1,5]benzothiazepine (Example 14) is reacted with N-methylpiperazine in toluene giving the base compound, which is then converted to the fumarate, m.p. 186°-188° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04157444 |
| Source dataset | uspto-grants-1979_06 |
| ORD ID | ord-f49d8204002941deb7c628af016484bc |
| Source note | uspto-grants-1979_06 |