Water → HCID 178520962, compound

Participants

Reaction Steps

To a suspension of lithium aluminum hydride (0.462 g) in THF (100 mL) was added dropwise a solution of methyl trans-4-[6-(cyclopropylmethoxy)-2H-indazol-2-yl]cyclohexanecarboxylate (4.00 g) in THF (100 mL) under ice-cooling. The reaction mixture was stirred under ice-cooling for 2 hr, and water (0.462 mL), 5N aqueous sodium hydroxide solution (0.462 mL) and water (0.462 mL) were carefully added successively thereto. The reaction mixture was stirred under ice-cooling for 30 min, and the resulting precipitate was filtered off. The obtained filtrate was concentrated under reduced pressure to give the title compound (3.51 g).

Provenance & Evidence