Sodium borohydride → HCID 178467818, compound

Participants

Reaction Steps

Sodium borohydride (0.306 g) was added to a solution of 4-{trans-4-[6-(cyclopropylmethoxy)-2H-indazol-2-yl]cyclohexyl}butan-2-one (2.75 g) in ethanol (100 mL) under ice-cooling in small portions. The reaction mixture was stirred at room temperature for 1 hr, and the mixture was concentrated under reduced pressure. The residue was diluted with water, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel chromatography (hexane/ethyl acetate) to give the title compound (2.46 g).

Provenance & Evidence