Hydrochloric Acid → HCID 178445667, compound

Participants

Reaction Steps

To a solution of 4-{trans-4-[6-(cyclopropylmethoxy)-2H-indazol-2-yl]cyclohexyl}butan-2-ol (2.45 g) and triethylamine (1.50 mL) in THF (50 mL) was added dropwise a solution of sulfonyl chloride (0.83 mL) in THF (50 mL) under ice-cooling, and the mixture was stirred for 1 hr under ice-cooling. The reaction mixture was poured into 1N hydrochloric acid under ice-cooling, and the mixture was extracted with ethyl acetate. The organic layer was washed with water, aqueous sodium hydrogen carbonate solution and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give the title compound (2.98 g).

Provenance & Evidence