Sodium Azide → HCID 178445666, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-{trans-4-[6-(cyclopropylmethoxy)-2H-indazol-2-yl]cyclohexyl}-1-methylpropyl methanesulfonate (2.95 g), sodium azide (1.37 g) and DMF (100 mL) was stirred at 80° C. for 2 hr. The reaction mixture was allowed to cool to room temperature, and concentrated under reduced pressure. The residue was diluted with ethyl acetate and water, and the organic layer was separated. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel chromatography (hexane/ethyl acetate) to give the title compound (2.50 g).

Provenance & Evidence