benzyl (2S)-2-aminopropanoate → HCID 67152901, compound

HRID 2368202Notes

Reaction equation

HRID 2368202 reaction equation
[Br:1][C:2]1[CH:30]=[CH:29][C:5]([CH2:6][CH:7]([CH2:11][P:12]([OH:28])([CH:14]([NH:16][C:17]([O:19][CH:20]([O:22][C:23](=[O:27])[CH:24]([CH3:26])[CH3:25])[CH3:21])=[O:18])[CH3:15])=[O:13])[C:8](O)=[O:9])=[CH:4][CH:3]=1.[CH2:31]([O:38][C:39](=[O:43])[C@H:40]([CH3:42])[NH2:41])[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[CH2:31]([O:38][C:39](=[O:43])[CH:40]([NH:41][C:8](=[O:9])[CH:7]([CH2:6][C:5]1[CH:29]=[CH:30][C:2]([Br:1])=[CH:3][CH:4]=1)[CH2:11][P:12]([OH:28])([CH:14]([NH:16][C:17]([O:19][CH:20]([O:22][C:23](=[O:27])[CH:24]([CH3:26])[CH3:25])[CH3:21])=[O:18])[CH3:15])=[O:13])[CH3:42])[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1

Participants

3

Reactant 2

HCID 726858benzyl (2S)-2-aminopropanoateHCID 67153158HCID 67153158, compound

Product 1

HCID 67152901HCID 67152901, compound

Procedure

Using 1 g of the compound from step 3 and 388 mg of alanine benzyl ester, the expected compound is obtained according to the protocol in step 4 of example 3. White solid.

Sources & evidence

ORD record
ord-34d08131da66476e82d3ec44e6ab62e3
Source dataset
uspto-grants-2014_04
Patent number
US08703747B2

Reaction notes

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