HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 178465080, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | tert-Butyl alaninate hydrochloride | HCID 11275390 | — |
| Reactant | HCID 178465408 | HCID 178465408 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178465080 | HCID 178465080 | 97% |
Reaction Steps
The compound from step 1 (0.9 g) is solubilised in 10 ml of DMF in nitrogen, and t-butyl alaninate hydrochloride (450 mg), 2.5 ml of DIEA (6 eq) and 1.98 g of TBTU (3 eq) are successively added. The mixture is stirred for 15 min at ambient temperature and the reaction is processed as in step 4 of example 3. 1.10 g of expected product (97%) is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08703747B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-23e6596847fd47a29375f0bf66bcaa6d |
| Source note | uspto-grants-2014_04 |