2,2,2-Trifluoroethyl Methanesulfonate → HCID 70115437, compound

HRID 2368237Notes

Reaction equation

HRID 2368237 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][NH:8][N:7]=1)=[O:5])[CH3:2].CS(O[CH2:19][C:20]([F:23])([F:22])[F:21])(=O)=O>>[CH2:1]([O:3][C:4]([C:6]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][N:8]([CH2:19][C:20]([F:23])([F:22])[F:21])[N:7]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 5565652,2,2-Trifluoroethyl MethanesulfonateHCID 178470496HCID 178470496, compound

Product 1

HCID 70115437HCID 70115437, compound

Procedure

The product was obtained as a single regioisomer according to the method described in example 4, step 2 starting from 4-nitro-1H-pyrazole-3-carboxylic acid ethyl ester and 2,2,2-trifluoroethyl methanesulfonate after purification by silica gel chromatography using a heptane/ethyl acetate gradient as yellow oil (568 mg, 84%).

Workup

  1. customThe product was obtained as a single regioisomer
  2. customafter purification by silica gel chromatography

Sources & evidence

ORD record
ord-276bef8f4c0f434aa973de5d349a090a
Source dataset
uspto-grants-2014_04
Patent number
US08703768B2

Reaction notes

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