HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexylamine → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid (3-cyclohexylcarbamoyl-1-methyl-1H-pyrazol-4-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexylamine | HCID 7965 | — |
| Reactant | 4-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester | HCID 70099200 | — |
| Product | 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid (3-cyclohexylcarbamoyl-1-methyl-1H-pyrazol-4-yl)-amide | HCID 58548289 | 45% |
Reaction Steps
According to the general method described in step 5 of example 27, reaction of cyclohexylamine with 4-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester provided the title compound (45%) as sticky yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08703768B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-1897910862f24df78fe1b1691cd30be6 |
| Source note | uspto-grants-2014_04 |