3,3-Difluoropyrrolidine → HCID 58548278, compound

HRID 2368256Notes

Reaction equation

HRID 2368256 reaction equation
[F:1][C:2]1([F:7])[CH2:6][CH2:5][NH:4][CH2:3]1.C[O:9][C:10]([C:12]1[C:16]([NH:17][C:18]([C:20]2[C:25]([NH:26][C:27]3[CH:28]=[N:29][CH:30]=[N:31][CH:32]=3)=[CH:24][CH:23]=[C:22]([CH:33]3[CH2:35][CH2:34]3)[N:21]=2)=[O:19])=[CH:15][N:14]([CH3:36])[N:13]=1)=O>>[F:1][C:2]1([F:7])[CH2:6][CH2:5][N:4]([C:10]([C:12]2[C:16]([NH:17][C:18]([C:20]3[C:25]([NH:26][C:27]4[CH:28]=[N:29][CH:30]=[N:31][CH:32]=4)=[CH:24][CH:23]=[C:22]([CH:33]4[CH2:35][CH2:34]4)[N:21]=3)=[O:19])=[CH:15][N:14]([CH3:36])[N:13]=2)=[O:9])[CH2:3]1

Participants

3

Reactant 2

HCID 27828273,3-DifluoropyrrolidineHCID 700992004-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester

Product 1

HCID 58548278HCID 58548278, compoundYield 14%

Procedure

According to the general method described in step 5 of example 27, reaction of 3,3-difluoropyrrolidine with 4-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester provided the title compound (14%) as sticky yellow solid.

Sources & evidence

ORD record
ord-672fc2d8cfa249ec8b9400dd6ecb14a1
Source dataset
uspto-grants-2014_04
Patent number
US08703768B2

Reaction notes

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