2-(Methylamino)ethanol → HCID 58548316, compound
Reaction equation
[CH3:1][NH:2][CH2:3][CH2:4][OH:5].CO[C:8]([C:10]1[C:14]([NH:15][C:16]([C:18]2[C:23]([NH:24][C:25]3[CH:26]=[N:27][CH:28]=[N:29][CH:30]=3)=[CH:22][CH:21]=[C:20]([CH:31]3[CH2:33][CH2:32]3)[N:19]=2)=[O:17])=[CH:13][N:12]([CH3:34])[N:11]=1)=[O:9]>>[OH:5][CH2:4][CH2:3][N:2]([CH3:1])[C:8]([C:10]1[C:14]([NH:15][C:16]([C:18]2[C:23]([NH:24][C:25]3[CH:26]=[N:27][CH:28]=[N:29][CH:30]=3)=[CH:22][CH:21]=[C:20]([CH:31]3[CH2:32][CH2:33]3)[N:19]=2)=[O:17])=[CH:13][N:12]([CH3:34])[N:11]=1)=[O:9]Participants
3
Procedure
According to the general method described in step 5 of example 27, reaction of 2-methylamino-ethanol with 4-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester provided the title compound (13%) as amorphous yellow solid.
Sources & evidence
- ORD record
- ord-2dc14a3d99e84ea98dea8623caf73588
- Source dataset
- uspto-grants-2014_04
- Patent number
- US08703768B2
Reaction notes
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