3-(Methylamino)propane-1,2-diol → HCID 58548233, compound
Reaction equation
[CH3:1][NH:2][CH2:3][CH:4]([OH:7])[CH2:5][OH:6].CO[C:10]([C:12]1[C:16]([NH:17][C:18]([C:20]2[C:25]([NH:26][C:27]3[CH:28]=[N:29][CH:30]=[N:31][CH:32]=3)=[CH:24][CH:23]=[C:22]([CH:33]3[CH2:35][CH2:34]3)[N:21]=2)=[O:19])=[CH:15][N:14]([CH3:36])[N:13]=1)=[O:11]>>[OH:7][CH:4]([CH2:5][OH:6])[CH2:3][N:2]([CH3:1])[C:10]([C:12]1[C:16]([NH:17][C:18]([C:20]2[C:25]([NH:26][C:27]3[CH:32]=[N:31][CH:30]=[N:29][CH:28]=3)=[CH:24][CH:23]=[C:22]([CH:33]3[CH2:35][CH2:34]3)[N:21]=2)=[O:19])=[CH:15][N:14]([CH3:36])[N:13]=1)=[O:11]Participants
3
Procedure
According to the general method described in step 5 of example 27, reaction of 3-methylamino-propane-1,2-diol with 4-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester provided the title compound (9%) as sticky yellow solid.
Sources & evidence
- ORD record
- ord-f444d5e5da6a4fdaadcd74e4b588025f
- Source dataset
- uspto-grants-2014_04
- Patent number
- US08703768B2
Reaction notes
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