3-Hydroxyazetidine → HCID 58548221, compound

HRID 2368269Notes

Reaction equation

HRID 2368269 reaction equation
[OH:1][CH:2]1[CH2:5][NH:4][CH2:3]1.C[O:7][C:8]([C:10]1[C:14]([NH:15][C:16]([C:18]2[C:23]([NH:24][C:25]3[CH:26]=[N:27][CH:28]=[N:29][CH:30]=3)=[CH:22][CH:21]=[C:20]([CH:31]3[CH2:33][CH2:32]3)[N:19]=2)=[O:17])=[CH:13][N:12]([CH3:34])[N:11]=1)=O>>[OH:1][CH:2]1[CH2:5][N:4]([C:8]([C:10]2[C:14]([NH:15][C:16]([C:18]3[C:23]([NH:24][C:25]4[CH:26]=[N:27][CH:28]=[N:29][CH:30]=4)=[CH:22][CH:21]=[C:20]([CH:31]4[CH2:33][CH2:32]4)[N:19]=3)=[O:17])=[CH:13][N:12]([CH3:34])[N:11]=2)=[O:7])[CH2:3]1

Participants

3

Reactant 2

HCID 15142903-HydroxyazetidineHCID 700992004-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester

Product 1

HCID 58548221HCID 58548221, compoundYield 13%

Procedure

According to the general method described in step 5 of example 27, reaction of 3-hydroxy-azetidine with 4-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester provided the title compound (13%) as sticky yellow solid.

Sources & evidence

ORD record
ord-2d3dac0db0cc42648e71f8037598bc70
Source dataset
uspto-grants-2014_04
Patent number
US08703768B2

Reaction notes

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