Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2368278Generated: November 2, 2026

2-Methylpyrrolidine → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid [4-(2-methyl-pyrrolidine-1-carbonyl)-pyridin-3-yl]-amide

https://huagongshe.com/reaction/2368278

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-MethylpyrrolidineHCID 13003—
Reactant3-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acidHCID 70098054—
Product6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid [4-(2-methyl-pyrrolidine-1-carbonyl)-pyridin-3-yl]-amideHCID 5476056614%

Reaction Steps

According to the general method described in step 3 of example 53, reaction of 2-methyl-pyrolidine with 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid provided the title compound (14%) as sticky yellow solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08703768B2
Source datasetuspto-grants-2014_04
ORD IDord-7feb3e9dec754bdca3c8c2eccdd5d888
Source noteuspto-grants-2014_04