HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclobutylamine → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid (4-cyclobutylcarbamoyl-pyridin-3-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclobutylamine | HCID 75645 | — |
| Reactant | 3-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid | HCID 70098054 | — |
| Product | 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid (4-cyclobutylcarbamoyl-pyridin-3-yl)-amide | HCID 54760569 | 35% |
Reaction Steps
According to the general method described in step 3 of example 53, reaction of cyclobutylamine with 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid provided the title compound (35%) as amorphous yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08703768B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-e65106f098674e0dac3b47b2cc587d4a |
| Source note | uspto-grants-2014_04 |