Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2368285Generated: October 31, 2026

3-Methoxypyrrolidine → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid [4-(3-methoxy-pyrrolidine-1-carbonyl)-pyridin-3-yl]-amide

https://huagongshe.com/reaction/2368285

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-MethoxypyrrolidineHCID 11355447—
Reactant3-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acidHCID 70098054—
Product6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid [4-(3-methoxy-pyrrolidine-1-carbonyl)-pyridin-3-yl]-amideHCID 5476075918%

Reaction Steps

According to the general method described in step 3 of example 53, reaction of 3-methoxy-pyrrolidine with 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid provided the title compound (18%) as off-white powder.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08703768B2
Source datasetuspto-grants-2014_04
ORD IDord-8fb4982cb19f4be984a86c1fa6d7a528
Source noteuspto-grants-2014_04