2-Aminopropanol → HCID 70650416, compound

HRID 2368293Notes

Reaction equation

HRID 2368293 reaction equation
[NH2:1][CH:2]([CH3:5])[CH2:3][OH:4].[CH:6]1([C:9]2[N:14]=[C:13]([C:15]([NH:17][C:18]3[CH:26]=[N:25][CH:24]=[CH:23][C:19]=3[C:20](O)=[O:21])=[O:16])[C:12]([NH:27][C:28]3[CH:29]=[N:30][CH:31]=[N:32][CH:33]=3)=[CH:11][CH:10]=2)[CH2:8][CH2:7]1>>[OH:4][CH2:3][CH:2]([NH:1][C:20]([C:19]1[CH:23]=[CH:24][N:25]=[CH:26][C:18]=1[NH:17][C:15]([C:13]1[C:12]([NH:27][C:28]2[CH:29]=[N:30][CH:31]=[N:32][CH:33]=2)=[CH:11][CH:10]=[C:9]([CH:6]2[CH2:8][CH2:7]2)[N:14]=1)=[O:16])=[O:21])[CH3:5]

Participants

3

Reactant 2

HCID 51262-AminopropanolHCID 700980543-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid

Product 1

HCID 70650416HCID 70650416, compoundYield 32%

Procedure

According to the general method described in step 3 of example 53, reaction of 2-amino-propan-1-ol with 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid provided the title compound (32%) as amorphous yellow solid.

Sources & evidence

ORD record
ord-8734d9256edf4c36b6af638e2f93aa62
Source dataset
uspto-grants-2014_04
Patent number
US08703768B2

Reaction notes

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