Ethanolamine → HCID 70097503, compound

HRID 2368295Notes

Reaction equation

HRID 2368295 reaction equation
[NH2:1][CH2:2][CH2:3][OH:4].[CH:5]1([C:8]2[N:13]=[C:12]([C:14]([NH:16][C:17]3[CH:25]=[N:24][CH:23]=[CH:22][C:18]=3[C:19](O)=[O:20])=[O:15])[C:11]([NH:26][C:27]3[CH:28]=[N:29][CH:30]=[N:31][CH:32]=3)=[CH:10][CH:9]=2)[CH2:7][CH2:6]1>>[OH:4][CH2:3][CH2:2][NH:1][C:19]([C:18]1[CH:22]=[CH:23][N:24]=[CH:25][C:17]=1[NH:16][C:14]([C:12]1[C:11]([NH:26][C:27]2[CH:28]=[N:29][CH:30]=[N:31][CH:32]=2)=[CH:10][CH:9]=[C:8]([CH:5]2[CH2:7][CH2:6]2)[N:13]=1)=[O:15])=[O:20]

Participants

3

Reactant 2

HCID 700EthanolamineHCID 700980543-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid

Product 1

HCID 70097503HCID 70097503, compoundYield 36%

Procedure

According to the general method described in step 3 of example 53, reaction of 2-aminoethanol with 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid provided the title compound (36%) as amorphous yellow solid.

Sources & evidence

ORD record
ord-f0b2e5dfb3ae4c22bb3b83b7c9a23051
Source dataset
uspto-grants-2014_04
Patent number
US08703768B2

Reaction notes

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