HCID 23090608, compound → HCID 58548360, compound

HRID 2368299Notes

Reaction equation

HRID 2368299 reaction equation
[CH3:1][O:2][CH2:3][CH:4]([NH:6]C)[CH3:5].[CH:8]1([C:11]2[N:16]=[C:15]([C:17]([NH:19][C:20]3[CH:28]=[N:27][CH:26]=[CH:25][C:21]=3[C:22]([OH:24])=O)=[O:18])[C:14]([NH:29][C:30]3[CH:31]=[N:32][CH:33]=[N:34][CH:35]=3)=[CH:13][CH:12]=2)[CH2:10][CH2:9]1>>[CH3:1][O:2][CH2:3][CH:4]([NH:6][C:22]([C:21]1[CH:25]=[CH:26][N:27]=[CH:28][C:20]=1[NH:19][C:17]([C:15]1[C:14]([NH:29][C:30]2[CH:35]=[N:34][CH:33]=[N:32][CH:31]=2)=[CH:13][CH:12]=[C:11]([CH:8]2[CH2:9][CH2:10]2)[N:16]=1)=[O:18])=[O:24])[CH3:5]

Participants

3

Reactant 2

HCID 23090608HCID 23090608, compoundHCID 700980543-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid

Product 1

HCID 58548360HCID 58548360, compoundYield 32%

Procedure

According to the general method described in step 3 of example 53, reaction of (2-methoxy-1-methyl-ethyl)-methyl-amine with 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid provided the title compound (32%) as amorphous yellow solid.

Sources & evidence

ORD record
ord-ac7c1a8a5362429e9708fb19f02d9102
Source dataset
uspto-grants-2014_04
Patent number
US08703768B2

Reaction notes

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