3-(Methylamino)propane-1,2-diol → HCID 58548241, compound

HRID 2368311Notes

Reaction equation

HRID 2368311 reaction equation
[CH3:1][NH:2][CH2:3][CH:4]([OH:7])[CH2:5][OH:6].[CH:8]1([C:11]2[N:16]=[C:15]([C:17]([NH:19][C:20]3[CH:28]=[N:27][CH:26]=[CH:25][C:21]=3[C:22]([OH:24])=O)=[O:18])[C:14]([NH:29][C:30]3[CH:31]=[N:32][CH:33]=[N:34][CH:35]=3)=[CH:13][CH:12]=2)[CH2:10][CH2:9]1>>[OH:7][CH:4]([CH2:5][OH:6])[CH2:3][N:2]([CH3:1])[C:22]([C:21]1[CH:25]=[CH:26][N:27]=[CH:28][C:20]=1[NH:19][C:17]([C:15]1[C:14]([NH:29][C:30]2[CH:31]=[N:32][CH:33]=[N:34][CH:35]=2)=[CH:13][CH:12]=[C:11]([CH:8]2[CH2:9][CH2:10]2)[N:16]=1)=[O:18])=[O:24]

Participants

3

Reactant 2

HCID 27341223-(Methylamino)propane-1,2-diolHCID 700980543-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid

Product 1

HCID 58548241HCID 58548241, compoundYield 19%

Procedure

According to the general method described in step 3 of example 53, reaction of 3-methylamino-propan-1,2-diol with 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid provided the title compound (19%) as sticky yellow solid.

Sources & evidence

ORD record
ord-a68c12cffb0647dd9ed5b8950d296004
Source dataset
uspto-grants-2014_04
Patent number
US08703768B2

Reaction notes

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