Methylamine → HCID 70100083, compound

Participants

Reaction Conditions

Reaction Steps

In an autoclave a mixture of methyl 2-amino-4-(diethylcarbamoyl)benzoate (490 mg, 1.96 mmol) and methylamine solution (33% in ethanol; 25 ml, 200 mmol) was stirred for 24 hrs at 90° C. The reaction mixture was concentrated. The crude product was purified by silica gel chromatography using EtOAc as eluent, providing the title compound as white solid (341 mg, 70%).

Provenance & Evidence