4-amino-N,1-dimethyl-1H-pyrazole-3-carboxamide hydrochloride → 3-Amino-N-(1-methyl-3-(methylcarbamoyl)-1H-pyrazol-4-yl)-6-(tetrahydrofuran-2-yl)pyrazine-2-carboxamide

HRID 2368319Notes

Reaction equation

HRID 2368319 reaction equation
CO[C:3]([C:5]1[C:10]([NH2:11])=[N:9][CH:8]=[C:7]([CH:12]2[CH2:16][CH2:15][CH2:14][O:13]2)[N:6]=1)=[O:4].Cl.[CH3:18][NH:19][C:20]([C:22]1[C:26]([NH2:27])=[CH:25][N:24]([CH3:28])[N:23]=1)=[O:21]>>[NH2:11][C:10]1[C:5]([C:3]([NH:27][C:26]2[C:22]([C:20](=[O:21])[NH:19][CH3:18])=[N:23][N:24]([CH3:28])[CH:25]=2)=[O:4])=[N:6][C:7]([CH:12]2[CH2:16][CH2:15][CH2:14][O:13]2)=[CH:8][N:9]=1

Participants

3

Reactant 2

HCID 446308974-amino-N,1-dimethyl-1H-pyrazole-3-carboxamide hydrochlorideHCID 700987903-Amino-6-(tetrahydrofuran-2-yl)pyrazine-2-carboxylic acid methyl ester

Product 1

HCID 701141133-Amino-N-(1-methyl-3-(methylcarbamoyl)-1H-pyrazol-4-yl)-6-(tetrahydrofuran-2-yl)pyrazine-2-carboxamideYield 64%

Procedure

According to the procedure described in step 2 of example 14, 3-amino-6-(tetrahydrofuran-2-yl)pyrazine-2-carboxylic acid methyl ester was reacted with 4-amino-1-methyl-1H-pyrazole-3-carboxylic acid methylamide hydrochloride to obtain the title compound as yellow solid (64%).

Sources & evidence

ORD record
ord-8ecf8209eeca44efa15db28cf87520fe
Source dataset
uspto-grants-2014_04
Patent number
US08703768B2

Reaction notes

Loading…