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HRID 2368325作成日：2026年10月25日

2-Propanol, 1-amino-2-methyl- → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid [4-(2-hydroxy-2-methyl-propylcarbamoyl)-pyridin-3-yl]-amide

https://huagongshe.com/reaction/2368325

反応式

関与物質

役割名称HCID仕込み量
反応物2-Propanol, 1-amino-2-methyl-HCID 95102—
反応物3-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acidHCID 70098928—
生成物6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid [4-(2-hydroxy-2-methyl-propylcarbamoyl)-pyridin-3-yl]-amideHCID 5854816174%

反応手順

According to the procedure described in step 3 of example 99, 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid (example 99, step 2) was reacted with 1-amino-2-methylpropan-2-ol, providing the title compound as yellow solid (74%).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08703768B2
出典データセットuspto-grants-2014_04
ORD IDord-f33e785af9d84756a259ae0a70da19d9
出典メモuspto-grants-2014_04