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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2368326Generated: October 25, 2026

Oxetan-3-amine hydrochloride → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid [4-(oxetan-3-ylcarbamoyl)-pyridin-3-yl]-amide

https://huagongshe.com/reaction/2368326

Reaction equation

Participants

RoleNameHCIDCharge
ReactantOxetan-3-amine hydrochlorideHCID 23062080—
Reactant3-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acidHCID 70098928—
Product6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid [4-(oxetan-3-ylcarbamoyl)-pyridin-3-yl]-amideHCID 5854821758%

Reaction Steps

According to the procedure described in step 3 of example 99, 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid (example 99, step 2) was reacted with oxetan-3-amine hydrochloride, providing the title compound as yellow solid (58%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08703768B2
Source datasetuspto-grants-2014_04
ORD IDord-efb85d52adcb4b79a0852343c0087b6a
Source noteuspto-grants-2014_04