2-Methoxyethylamine → Ethyl 5-bromo-2-((2-methoxyethyl)amino)pyrimidine-4-carboxylate

Participants

Reaction Conditions

Reaction Steps

A solution of 5-bromo-2-methanesulfonyl-pyrimidine-4-carboxylic acid ethyl ester (86 mg, 0.27 mmol) in dichloromethane (2 ml) was treated with 2-methoxyethylamine (124 μl, 1.44 mmol) under argon atmosphere and heated to 45° C. for 2 h. All volatiles were removed and the product was obtained after purification by silica gel chromatography using a heptane/ethyl acetate gradient as colorless oil (72 mg, 82%).

Provenance & Evidence