HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-amino-N,1-dimethyl-1H-pyrazole-3-carboxamide hydrochloride → 2-(2-Methoxy-ethylamino)-5-(pyrimidin-5-ylamino)-pyrimidine-4-carboxylic acid (1-methyl-3-methylcarbamoyl-1H-pyrazol-4-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-amino-N,1-dimethyl-1H-pyrazole-3-carboxamide hydrochloride | HCID 44630897 | — |
| Reactant | 2-(2-Methoxy-ethylamino)-5-(pyrimidin-5-ylamino)-pyrimidine-4-carboxylic acid ethyl ester | HCID 70097510 | — |
| Product | 2-(2-Methoxy-ethylamino)-5-(pyrimidin-5-ylamino)-pyrimidine-4-carboxylic acid (1-methyl-3-methylcarbamoyl-1H-pyrazol-4-yl)-amide | HCID 86660192 | — |
Reaction Steps
The product was obtained starting from 2-(2-methoxy-ethylamino)-5-(pyrimidin-5-ylamino)-pyrimidine-4-carboxylic acid ethyl ester (11 mg, 35 μmol) and 4-amino-1-methyl-1H-pyrazole-3-carboxylic acid methylamide hydrochloride (20 mg, 105 μmol) according to the method described in example 104 after purification by preparative HPLC using an acetonitrile/water gradient as yellow solid (0.5 mg, 3%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08703768B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-2ae97e5e91cd485b891a6a4938d1e843 |
| Source note | uspto-grants-2014_04 |