Lithium Hydroxide → HCID 70099899, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 5-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-2-methyl-thiazole-4-carboxylic acid ethyl ester (70 mg, 0.16 mmol) in a THF/ethanol mixture (2.5 ml; 1.5:1) was cooled to 0° C. and treated with lithium hydroxide (0.82 ml; 1N aqueous solution). After 15 min, the cooling bath was removed and the reaction mixture was stirred at 50° C. overnight. The reaction mixture was cooled to r.t. and 0.84 ml 1M HCl was added. The suspension was filtered, the solid was washed with water and THF and dried in vacuo to yield 28 mg (43%) of a yellow solid.

Provenance & Evidence