Methylamine hydrochloride → HCID 58548220, compound

HRID 2368339Notes

Reaction equation

HRID 2368339 reaction equation
[CH:1]1([C:4]2[N:9]=[C:8]([C:10]([NH:12][C:13]3[S:17][C:16]([CH3:18])=[N:15][C:14]=3[C:19](O)=[O:20])=[O:11])[C:7]([NH:22][C:23]3[CH:24]=[N:25][CH:26]=[N:27][CH:28]=3)=[N:6][CH:5]=2)[CH2:3][CH2:2]1.Cl.[CH3:30][NH2:31]>>[CH3:18][C:16]1[S:17][C:13]([NH:12][C:10]([C:8]2[C:7]([NH:22][C:23]3[CH:28]=[N:27][CH:26]=[N:25][CH:24]=3)=[N:6][CH:5]=[C:4]([CH:1]3[CH2:3][CH2:2]3)[N:9]=2)=[O:11])=[C:14]([C:19](=[O:20])[NH:31][CH3:30])[N:15]=1

Participants

3

Reactant 2

HCID 6364545Methylamine hydrochlorideHCID 70099899HCID 70099899, compound

Product 1

HCID 58548220HCID 58548220, compound

Procedure

The product was obtained starting from 5-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-2-methyl-thiazole-4-carboxylic acid (28 mg, 0.07 mmol) and methylamine hydrochloride (6.2 mg, 0.09 mmol) according to the method described in example 64, step 6 as yellow solid (16 mg, 44%).

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-513ee7b6bc724591bc53bcf1b51e7550
Source dataset
uspto-grants-2014_04
Patent number
US08703768B2

Reaction notes

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