HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-amino-N,1-dimethyl-1H-pyrazole-5-carboxamide → 5-Bromo-2-cyclobutyl-pyrimidine-4-carboxylic acid (1-methyl-5-methylcarbamoyl-1H-pyrazol-4-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-amino-N,1-dimethyl-1H-pyrazole-5-carboxamide | HCID 6485370 | — |
| Reactant | 5-Bromo-2-cyclobutylpyrimidine-4-carboxylic acid | HCID 70097174 | — |
| Product | 5-Bromo-2-cyclobutyl-pyrimidine-4-carboxylic acid (1-methyl-5-methylcarbamoyl-1H-pyrazol-4-yl)-amide | HCID 86660196 | — |
Reaction Steps
The product was obtained starting from 5-bromo-2-cyclobutyl-pyrimidine-4-carboxylic acid (37 mg, 0.14 mmol) and 4-amino-2-methyl-2H-pyrazole-3-carboxylic acid methylamide (29 mg, 0.19 mmol) according to the method described in example 64, step 6 after purification by preparative HPLC using an acetonitrile/water gradient as off-white solid (24 mg, 42%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08703768B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-2d41d76350134634a2ec19913f13258c |
| Source note | uspto-grants-2014_04 |