HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-amino-N,1-dimethyl-1H-pyrazole-5-carboxamide → 3-(Pyrimidin-5-ylamino)-6-pyrrolidin-1-yl-pyrazine-2-carboxylic acid (1-methyl-5-methylcarbamoyl-1H-pyrazol-4-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-amino-N,1-dimethyl-1H-pyrazole-5-carboxamide | HCID 6485370 | — |
| Reactant | 3-(Pyrimidin-5-ylamino)-6-pyrrolidin-1-yl-pyrazine-2-carboxylic acid | HCID 70096947 | — |
| Product | 3-(Pyrimidin-5-ylamino)-6-pyrrolidin-1-yl-pyrazine-2-carboxylic acid (1-methyl-5-methylcarbamoyl-1H-pyrazol-4-yl)-amide | HCID 58548144 | — |
Reaction Steps
The product was obtained starting from 3-(pyrimidin-5-ylamino)-6-pyrrolidin-1-yl-pyrazine-2-carboxylic acid (30 mg, 94 μmol) and 4-amino-2-methyl-2H-pyrazole-3-carboxylic acid methylamide (19 mg, 123 μmol) according to the method described in example 64, step 6 after purification by preparative HPLC using an acetonitrile/water gradient as yellow solid (10 mg, 26%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08703768B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-85e72df72301406c9708c15b4bcaa1c8 |
| Source note | uspto-grants-2014_04 |