4-amino-N,1-dimethyl-1H-pyrazole-5-carboxamide → HCID 54760943, compound

HRID 2368385Notes

Reaction equation

HRID 2368385 reaction equation
[CH2:1]([C:5]1[N:10]=[C:9]([C:11]([OH:13])=O)[C:8]([NH:14][C:15]2[CH:16]=[N:17][CH:18]=[N:19][CH:20]=2)=[CH:7][N:6]=1)[CH:2]([CH3:4])[CH3:3].[CH3:21][NH:22][C:23]([C:25]1[N:26]([CH3:31])[N:27]=[CH:28][C:29]=1[NH2:30])=[O:24]>>[CH3:31][N:26]1[C:25]([C:23](=[O:24])[NH:22][CH3:21])=[C:29]([NH:30][C:11]([C:9]2[C:8]([NH:14][C:15]3[CH:16]=[N:17][CH:18]=[N:19][CH:20]=3)=[CH:7][N:6]=[C:5]([CH2:1][CH:2]([CH3:3])[CH3:4])[N:10]=2)=[O:13])[CH:28]=[N:27]1

Participants

3

Reactant 2

HCID 64853704-amino-N,1-dimethyl-1H-pyrazole-5-carboxamideHCID 70097413HCID 70097413, compound

Product 1

HCID 54760943HCID 54760943, compound

Procedure

The product was obtained starting from 2-isobutyl-5-(pyrimidin-5-ylamino)-pyrimidine-4-carboxylic acid (60 mg, 0.22 mmol; example 331, step 1) and 4-amino-2-methyl-2H-pyrazole-3-carboxylic acid methylamide (44 mg, 0.28 mmol) according to the method described in example 64, step 6 after purification by preparative HPLC using an acetonitrile/water gradient as yellow solid (42 mg, 47%).

Workup

  1. customThe product was obtained
  2. customafter purification by preparative HPLC

Sources & evidence

ORD record
ord-fdab230c857c4488ae6b38a4e12ede76
Source dataset
uspto-grants-2014_04
Patent number
US08703768B2

Reaction notes

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