4-amino-N,1-dimethyl-1H-pyrazole-5-carboxamide → HCID 58548165, compound

HRID 2368390Notes

Reaction equation

HRID 2368390 reaction equation
[N:1]1[CH:6]=[C:5]([NH:7][C:8]2[C:9]([C:20](O)=[O:21])=[N:10][C:11]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[N:12][CH:13]=2)[CH:4]=[N:3][CH:2]=1.[CH3:23][NH:24][C:25]([C:27]1[N:28]([CH3:33])[N:29]=[CH:30][C:31]=1[NH2:32])=[O:26]>>[CH3:33][N:28]1[C:27]([C:25](=[O:26])[NH:24][CH3:23])=[C:31]([NH:32][C:20]([C:9]2[C:8]([NH:7][C:5]3[CH:4]=[N:3][CH:2]=[N:1][CH:6]=3)=[CH:13][N:12]=[C:11]([O:14][CH2:15][C:16]([F:19])([F:17])[F:18])[N:10]=2)=[O:21])[CH:30]=[N:29]1

Participants

3

Reactant 2

HCID 64853704-amino-N,1-dimethyl-1H-pyrazole-5-carboxamideHCID 70098061HCID 70098061, compound

Product 1

HCID 58548165HCID 58548165, compound

Procedure

The product was obtained starting from 5-(pyrimidin-5-ylamino)-2-(2,2,2-trifluoro-ethoxy)-pyrimidine-4-carboxylic acid (50 mg, 0.16 mmol) and 4-amino-2-methyl-2H-pyrazole-3-carboxylic acid methylamide (32 mg, 0.21 mmol) according to the method described in example 64, step 6 as yellow solid (50 mg, 69%).

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-f6605bf370674377b18ae6215c258040
Source dataset
uspto-grants-2014_04
Patent number
US08703768B2

Reaction notes

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