4-amino-N,1-dimethyl-1H-pyrazole-5-carboxamide → HCID 54761816, compound

HRID 2368395Notes

Reaction equation

HRID 2368395 reaction equation
[N:1]1[CH:6]=[C:5]([NH:7][C:8]2[C:9]([C:20]([OH:22])=O)=[N:10][C:11]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:12][N:13]=2)[CH:4]=[N:3][CH:2]=1.[CH3:23][NH:24][C:25]([C:27]1[N:28]([CH3:33])[N:29]=[CH:30][C:31]=1[NH2:32])=[O:26]>>[CH3:33][N:28]1[C:27]([C:25](=[O:26])[NH:24][CH3:23])=[C:31]([NH:32][C:20]([C:9]2[C:8]([NH:7][C:5]3[CH:4]=[N:3][CH:2]=[N:1][CH:6]=3)=[N:13][CH:12]=[C:11]([O:14][CH2:15][C:16]([F:17])([F:18])[F:19])[N:10]=2)=[O:22])[CH:30]=[N:29]1

Participants

3

Reactant 2

HCID 64853704-amino-N,1-dimethyl-1H-pyrazole-5-carboxamideHCID 70095749HCID 70095749, compound

Product 1

HCID 54761816HCID 54761816, compound

Procedure

The product was obtained starting from 3-(pyrimidin-5-ylamino)-6-(2,2,2-trifluoro-ethoxy)-pyrazine-2-carboxylic acid (114 mg, 0.36 mmol) and 4-amino-2-methyl-2H-pyrazole-3-carboxylic acid methylamide (67 mg, 0.43 mmol) according to the method described in example 64, step 6 as yellow solid (92 mg, 56%).

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-808243cea8ac4752b1238d7386105696
Source dataset
uspto-grants-2014_04
Patent number
US08703768B2

Reaction notes

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