HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 57513818, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- | HCID 85083 | — |
| Reactant | 2-Amino-4-phenylpyrimidine | HCID 598777 | — |
| Reactant | Tetramethylfluoroformamidinium hexafluorophosphate | HCID 2774761 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 57513818 | HCID 57513818 | — |
Reaction Steps
4-Phenyl-pyrimidin-2-ylamine (200 mg, 1 mmol), Boc-L-Pro-OH (327 mg, 1.3 mmol) and TFFH (Fluoro-N,N,N′-tetramethylformamidinium hexafluorophosphate; 463 mg, 1.3 mmol) were stirred as a solution in DCM (10 mL) containing triethyl amine (300 mL, 2 mmol). Purification by silica gel chromatography gave the title compound. m/z 369.1 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08703761B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-3ac417ae8e8241dba56cfab3ecadc601 |
| Source note | uspto-grants-2014_04 |