Hydrogen Bromide → HCID 57513820, compound

Participants

Reaction Steps

33% HBr (100 mL) was added to a solution of {1-[5-(4-Fluoro-phenoxy)-4-(4-fluoro-phenyl)-thiazol-2-ylcarbamoyl]-1-methyl-ethyl}-carbamic acid benzyl ester (12 g, 23 mmol) in acetic acid (50 mL). The mixture was stirred at room temperature for 18 h. Most of acetic acid was removed by evaporation under vacuum. The mixture was basified with 1M NaOH, and the product was extracted with dichloromethane. The dichloromethane extract was washed with brine, dried over Na2SO4 and concentrated. The residue was chromatographed to give the title compound. m/z 390.9 (MH+).

Provenance & Evidence