HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 57513822, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | N-((Benzyloxy)carbonyl)-2-methylalanine | HCID 294936 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | HCID 57476894 | HCID 57476894 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 57513822 | HCID 57513822 | — |
Reaction Steps
A mixture of 2-Benzyloxycarbonylamino-2-methyl-propionic acid (360 mg, 1.52 mmol), HBTU (576 mg, 1.52 mmol) and Et3N (0.21 mL, 1.5 mmol) in DMF (4 mL) was stirred at room temperature for 30 min. To this was added a solution of 4-(2-Amino-4-cyclopropyl-thiazol-5-yloxy)-benzonitrile (260 mg, 1.01 mmol) in DMF (4 mL). The mixture was heated at 85° C. for 18 h and partitioned between EtOAc and 3M HCl. The organic extract was dried over MgSO4, concentrated and chromatographed to give the title compound. m/z 477.1 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08703761B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-5ef81903ed0041088b0281f6d3368a52 |
| Source note | uspto-grants-2014_04 |