Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | N-((1,1-dimethylethoxy)carbonyl)-2-methyl-alanine | HCID 2733845 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 57476895 | HCID 57476895 | — |
| Product | HCID 57513717 | HCID 57513717 | — |
Reaction Steps
To a solution of 2-tert-Butoxycarbonylamino-2-methyl-propionic acid (1.5 eq) and 4-(4-Fluoro-phenyl)-5-morpholin-4-yl-thiazol-2-ylamine (1 eq)) in DMF (50 mL) were added HATU (1.5 eq) and TEA (2 eq). Reaction was stirred at 60° C. overnight. Aqueous work up followed by silica gel chromatography afforded desired product. LCMS Method 10 Rt=1.51 (M+1=465.1. M−1=463.1). 1H NMR (400 MHz, DMSO-D6) ppm 1.21 (s, 1H) 1.28-1.40 (m, 14H) 2.80-2.87 (m, 4H) 3.70-3.77 (m, 4H) 7.21-7.27 (m, 2H) 8.10-8.16 (m, 2H) 11.59 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08703761B2 |
|---|
| Source dataset | uspto-grants-2014_04 |
|---|
| ORD ID | ord-8f262dd5002c40cd837e9c0fd1b17c2b |
|---|
| Source note | uspto-grants-2014_04 |
|---|
