Hydrogen Bromide → HCID 57513827, compound

Participants

Reaction Steps

A mixture of 2-(2-Benzyloxycarbonylamino-2-methyl-propionylamino)-4-phenyl-thiazole-5-carboxylic acid ethyl ester (1.57 g, 3.36 mmol) and 33% HBr (in acetic acid, 8 mL) in acetic acid (7 mL) was stirred at RT for 2 h, basified carefully to pH 7˜8 by addition of aqueous KOH, and the product was extracted with ethyl acetate, dried over MgSO4, concentrated and chromatographed to give the title compound. m/z 334.1 (MH+).

Provenance & Evidence