Potassium Hydroxide → HCID 57513829, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-[2-(4-Fluoro-benzoylamino)-2-methyl-propionylamino]-4-phenyl-thiazole-5-carboxylic acid ethyl ester (357 mg, 0.785 mmol) and concentrated aqueous KOH (2 mL) in a mixture of THF (3 mL) and ethanol (5 mL) was heated at 65° C. for 2 h, cooled to RT and partitioned between ethyl acetate and 3 M HCl. The combined organic extract was dried and concentrated to give the title compound. m/z 428.1 (MH+).

Provenance & Evidence