Trifluoroacetic acid → HCID 57513704, compound

Participants

Reaction Steps

A mixture of 4-{2-[2-(4-Fluoro-benzoylamino)-2-methyl-propionylamino]-4-phenyl-thiazole-5-carbonyl}-piperazine-1-carboxylic acid tert-butyl ester (120 mg) and TFA (3 mL) in dichloromethane (3 mL) was stirred at RT for 1 h. The mixture was concentrated, and the residue was partitioned between ethyl acetate and aq. K2CO3. The organic extract was dried over MgSO4 and concentrated. The residue was taken up in dichloromethane-methanol (3:1 v/v), and 2 M HCl (in ether, 100 uL) was added. The mixture was stirred at RT for 10 min and concentrated to give hydrochloride salt of the title compound. LCMS method A, retention time 1.0 min. m/z 496.1 (M+H+).

Provenance & Evidence