Triethylamine → HCID 57513831, compound

Participants

Reaction Steps

A mixture of 4-Fluoro-N-[1-(5-hydroxymethyl-4-phenyl-thiazol-2-ylcarbamoyl)-1-methyl-ethyl]-benzamide (82 mg, 0.20 mmol), MsCl (40 uL) and triethylamine (160 uL) in dichloromethane (3 mL) was stirred at RT for 20 min and concentrated. The residue was taken up in MeCN (5 mL), and N-Boc piperazine (120 mg, 0.644 mmol) and triethylamine (160 uL) were added. The mixture was stirred at RT for 20 min and partitioned between ethyl acetate and aq. K2CO3. The combined organic extract was dried over MgSO4, concentrated and chromatographed to give the title compound. m/z 582.2 (MH+).

Provenance & Evidence