Triethylamine → HCID 57513747, compound

Participants

Reaction Steps

A mixture of 2-Amino-N-[5-(4-fluoro-benzoyl)-4-trifluoromethyl-thiazol-2-yl]-2-methyl-propionamide (150 mg, 0.400 mmol), 1-methylcyclopropyl carboxylic acid (80 mg, 0.80 mmol), triethylamine (140 uL, 1.00 mmol) and HBTU (300 mg, 0.809 mmol) was stirred at RT for 18 h, partitioned between ethyl acetate and, sequentially, 3 M HCl and aqueous KOH. The organic extract was dried over MgSO4, concentrated and purified by HPLC to give the title compound. m/z 458.3 (MH+). 1H NMR (CDCl3) δ 7.91 (dd, J=8, 4 Hz, 2H), 7.16 (t, J=8 Hz, 2H), 6.04 (br s, 1H), 1.63 (s, 6H), 1.38 (s, 3H), 1.30-1.25 (m, 2H), 0.70-0.65 (m, 2H), retention time 1.42 min (method A).

Provenance & Evidence