[Hydroxy(tosyloxy)iodo]benzene → HCID 57513836, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-Fluoro-1-(4-fluoro-phenyl)-4-methyl-pentane-1,3-dione (900 mg) and Koser's reagent (4.2 g) in MeCN (20 mL) was heated at 80° C. for 50 min. The mixture was cooled to RT, and thiourea (820 mg) was added. The mixture was heated at 80° C. for 3 h., cooled to RT and partitioned between ethyl acetate and aq. KOH. The organic extract was dried over MgSO4, concentrated and chromatographed to give the title compound. m/z 283.2 (MH+). 1H NMR (DMSO-d6) 7.81 (dd, J=8, 4 Hz, 2H), 7.73 (s, 2H), 7.32 (t, J=8 Hz, 2H), 1.61 (d, J=20 Hz, 6H).

Provenance & Evidence