Morpholine → HCID 57476895, compound

Participants

Reaction Steps

5-Bromo-4-(4-fluoro-phenyl)-thiazole-2-ylamine and morpholine (6 eq) were stirred for 30 minutes at 120 C, under microwave heat. Triturated with ethyl acetate/n-Heptane solvent mixture (1:2 ratio) to afford the title compound pure. LCMS Method A Rt=1.14 (M+1=280.0, M−1=278.1). 1H NMR (400 MHz, DMSO-D6) 2.67-2.75 (m, 4H) 3.67-3.74 (m, 4H) 6.87 (s, 2H) 7.14-7.20 (m, 2H) 8.11 (ddd, J=12.41, 5.53, 3.03 Hz, 2H).

Provenance & Evidence