Hydrochloric Acid → HCID 15563282, compound

Participants

Reaction Conditions

Reaction Steps

The crude N-(1-benzyl-5-phenyl-1H-1,2,4-triazol-3-yl)benzamide was dissolved in 5 ml of MeOH. It was stirred and treated with 5 ml of 6N HCl. It was heated at 60° C. for overnight. It was cooled to rt and added to a stirred 4N NaOH (10 ml) in an ice bath. It was extracted with DCM. The combined DCM layer was dried with MgSO4 and rotavapped. The crude was purified by column chromatography with heptane/EtOAc gradient to yield 1-benzyl-5-phenyl-1H-1,2,4-triazol-3-amine (340 mg, 45.3% for 3 steps). 1H NMR (400 MHz, MeOD) 5.24 (br. s., 2H) 7.13 (br. s., 2H) 7.30 (br. s., 4H) 7.52 (br. s., 6H), LCMS method A, (M+H)+ 251.1, ret T=1.12 min.

Provenance & Evidence