Hydrochloric Acid → HCID 57476901, compound

Participants

Reaction Steps

To a solution of Ethyl-2-(2-(4-fluorobenzamido)-2-methylpropanamido)-4-(4-fluorophenyl)thiazole-5-carboxylate (4.3 g, 9 mmol) in EtOH (25 mL) was added KOH (1 eq) in water (25 mL). The reaction was stirred at 65 C for 15 hours followed by stirring at room temperature over 3 days. It was then acidified with 1 N HCl and the resulting precipitates were collected by filtration and dried to afford the title compound. 1H NMR (400 MHz, DMSO-d6) ppm 1.53 (s, 6H) 7.20 (t, J=8.97 Hz, 2H) 7.32 (t, J=8.84 Hz, 2H) 7.70 (dd, J=8.72, 5.68 Hz, 2H) 8.03 (dd, J=8.72, 5.56 Hz, 2H) 8.64 (s, 1H) 12.43 (s, 1H) 12.94 (br. s., 1H). MS m/z 446 (M+H), 444 (M−1).

Provenance & Evidence